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王學雷

    亞博游戲腫瘤科副主任(ren)、腫瘤放療科(ke)主任,主(zhu)任醫(yi)師,教授,碩士研究生(sheng)導師。山東(dong)(dong)(dong)生(sheng)物(wu)醫(yi)學(xue)工程學(xue)會(hui)(hui)生(sheng)物(wu)治(zhi)療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)副主(zhu)任委(wei)(wei)員(yuan),山東(dong)(dong)(dong)省腫(zhong)瘤(liu)微創治(zhi)療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)副主(zhu)任委(wei)(wei)員(yuan),山東(dong)(dong)(dong)省抗癌協會(hui)(hui)化(hua)療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)委(wei)(wei)員(yuan),山東(dong)(dong)(dong)省醫(yi)師協會(hui)(hui)化(hua)療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)委(wei)(wei)員(yuan),山東(dong)(dong)(dong)抗癌協會(hui)(hui)放療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)委(wei)(wei)員(yuan),山東(dong)(dong)(dong)省抗癌協會(hui)(hui)腫(zhong)瘤(liu)臨床協作專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)委(wei)(wei),山東(dong)(dong)(dong)抗癌協會(hui)(hui)腫(zhong)瘤(liu)生(sheng)物(wu)治(zhi)療(liao)專(zhuan)業委(wei)(wei)員(yuan)會(hui)(hui)委(wei)(wei)員(yuan)。 

    擅長(chang)各種惡(e)性(xing)(xing)腫(zhong)(zhong)瘤的(de)(de)綜合治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao),如頭(tou)勁腫(zhong)(zhong)瘤、肺癌(ai)(ai)(ai)(ai)、消(xiao)化(hua)(hua)道腫(zhong)(zhong)瘤、胰(yi)腺(xian)癌(ai)(ai)(ai)(ai)、肝癌(ai)(ai)(ai)(ai)、乳(ru)腺(xian)癌(ai)(ai)(ai)(ai)、婦科(ke)腫(zhong)(zhong)瘤及(ji)惡(e)性(xing)(xing)淋巴瘤的(de)(de)化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)、放(fang)療(liao)(liao)(liao)(liao)(liao)及(ji)生(sheng)(sheng)(sheng)物治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)。從事腫(zhong)(zhong)瘤臨床醫療(liao)(liao)(liao)(liao)(liao)、教學和科(ke)研亞博游戲網站23年。主要研究領域為惡(e)性(xing)(xing)腫(zhong)(zhong)瘤的(de)(de)化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)和放(fang)射治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)。通過綜合治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao),放(fang)療(liao)(liao)(liao)(liao)(liao)、化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)和手術(shu)的(de)(de)合理(li)安排保留了早期乳(ru)腺(xian)癌(ai)(ai)(ai)(ai)、直腸癌(ai)(ai)(ai)(ai)病人(ren)的(de)(de)器官和功能,提高(gao)了病人(ren)的(de)(de)生(sheng)(sheng)(sheng)存質(zhi)量。應用(yong)(yong)生(sheng)(sheng)(sheng)物靶向治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao),免疫治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)減輕了治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)的(de)(de)副(fu)作用(yong)(yong),提高(gao)了治(zhi)(zhi)(zhi)(zhi)愈率(lv)(lv)。應用(yong)(yong)局(ju)部(bu)治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)如體腔化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)配(pei)合熱(re)療(liao)(liao)(liao)(liao)(liao)技(ji)術(shu)治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)惡(e)性(xing)(xing)體腔積液,改善了病人(ren)的(de)(de)生(sheng)(sheng)(sheng)存率(lv)(lv)質(zhi)量。應用(yong)(yong)鎖骨下靜脈穿刺置管技(ji)術(shu),采用(yong)(yong)電子(zi)化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)泵,使化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)藥(yao)持續滴注,提高(gao)了化(hua)(hua)療(liao)(liao)(liao)(liao)(liao)效果。開(kai)展(zhan)(zhan)了精確放(fang)療(liao)(liao)(liao)(liao)(liao)技(ji)術(shu),三(san)維適形放(fang)療(liao)(liao)(liao)(liao)(liao)(3D-CRT),調(diao)強放(fang)療(liao)(liao)(liao)(liao)(liao)(IMRT),提高(gao)了腫(zhong)(zhong)瘤放(fang)療(liao)(liao)(liao)(liao)(liao)療(liao)(liao)(liao)(liao)(liao)效。在省內(nei)較(jiao)(jiao)早開(kai)展(zhan)(zhan)了腫(zhong)(zhong)瘤介入治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)技(ji)術(shu),開(kai)展(zhan)(zhan)了對原發性(xing)(xing)肝癌(ai)(ai)(ai)(ai)、胰(yi)腺(xian)癌(ai)(ai)(ai)(ai)、胃腸道腫(zhong)(zhong)瘤及(ji)婦科(ke)腫(zhong)(zhong)瘤的(de)(de)介入治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao)。較(jiao)(jiao)早開(kai)展(zhan)(zhan)了腫(zhong)(zhong)瘤分子(zi)靶向治(zhi)(zhi)(zhi)(zhi)療(liao)(liao)(liao)(liao)(liao),提高(gao)了患者的(de)(de)生(sheng)(sheng)(sheng)存。

    主持(chi)課題(ti):直(zhi)腸癌術(shu)前放療(liao)(liao)(liao)聯(lian)合(he)替吉(ji)奧(ao)化療(liao)(liao)(liao)的(de)(de)Ⅱ期(qi)臨(lin)床研(yan)究,肝(gan)動(dong)脈灌注化療(liao)(liao)(liao)治療(liao)(liao)(liao)肝(gan)轉移瘤的(de)(de)臨(lin)床研(yan)究。課題(ti):全反式(shi)(shi)維(wei)(wei)甲酸聯(lian)合(he)順(shun)鉑誘導(dao)NSCLC細胞(bao)凋亡(wang)(wang)及(ji)(ji)機制(zhi)的(de)(de)研(yan)究,該(gai)項(xiang)實驗研(yan)究成果(guo)(guo)鑒(jian)定結(jie)論達國際先進(jin)水平,在分子(zi)水平上揭示了全反式(shi)(shi)維(wei)(wei)甲酸聯(lian)合(he)順(shun)鉑誘導(dao)肺(fei)腺(xian)癌細胞(bao)凋亡(wang)(wang)及(ji)(ji)其(qi)機制(zhi),為全反式(shi)(shi)維(wei)(wei)甲酸應(ying)用于肺(fei)癌臨(lin)床治療(liao)(liao)(liao)提(ti)供了實驗依據,為肺(fei)癌治療(liao)(liao)(liao)提(ti)供了新(xin)的(de)(de)途(tu)徑。《全反式(shi)(shi)維(wei)(wei)甲酸增(zeng)強順(shun)鉑對(dui)(dui)A549細胞(bao)化療(liao)(liao)(liao)敏(min)感性及(ji)(ji)對(dui)(dui)Survivin mRNA和COX-2 mRNA表(biao)達的(de)(de)影響》和《全反式(shi)(shi)維(wei)(wei)甲酸與順(shun)鉑聯(lian)合(he)對(dui)(dui)肺(fei)腺(xian)癌A549細胞(bao)株增(zeng)殖與凋亡(wang)(wang)影響的(de)(de)觀察(cha)》在國內核心期(qi)刊《中國腫瘤臨(lin)床》及(ji)(ji)《中華腫瘤防治雜志》發表(biao),該(gai)項(xiang)成果(guo)(guo)獲2012年淄博市科(ke)技進(jin)步三等獎。已發表(biao)學(xue)術(shu)論文(wen)23篇,主編(bian)專(zhuan)著兩部,參編(bian)專(zhuan)著一部。

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